Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Black, Maureen M. | - |
dc.contributor.author | Baqui, Abdullah H. | - |
dc.contributor.author | Zaman, K. | - |
dc.contributor.author | Persson, Lars Ake | - |
dc.contributor.author | Arifeen, Shams El | - |
dc.contributor.author | Le, Katherine | - |
dc.contributor.author | McNary, Scot W. | - |
dc.contributor.author | Parveen, Monowara | - |
dc.contributor.author | Hamadani, Jena D. | - |
dc.contributor.author | Black, Robert E. | - |
dc.date.accessioned | 2015-03-15T04:27:55Z | - |
dc.date.available | 2015-03-15T04:27:55Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.citation | Am J Clin Nutr 2004 Oct;80(4):903-10 | en |
dc.identifier.uri | http://hdl.handle.net/123456789/5694 | - |
dc.description.abstract | Abstract BACKGROUND: Iron and zinc deficiency are prevalent during infancy in low-income countries. OBJECTIVES: The objectives were to examine whether a weekly supplement of iron, zinc, iron+zinc, or a micronutrient mix (MM) of 16 vitamins and minerals would alter infant development and behavior. DESIGN: The participants were 221 infants from rural Bangladesh at risk of micronutrient deficiencies. Development and behavior were evaluated at 6 and 12 mo of age by using the Bayley Scales of Infant Development II and the Home Observation Measurement of Environment (HOME) scale. In this double-blind trial, the infants were randomly assigned to 1 of 5 treatment conditions: iron (20 mg), zinc (20 mg), iron+zinc, MM (16 vitamins and minerals, including iron and zinc), or riboflavin weekly from 6 to 12 mo. Multivariate analyses were conducted to examine the change in development and behavior for each supplementation group, with control for maternal education, HOME score, months breastfed, anemia, growth at 6 mo, and change in growth from 6 to 12 mo. RESULTS: Iron and zinc administered together and with other micronutrients had a beneficial effect on infant motor development. Iron and zinc administered individually and in combination had a beneficial effect on orientation-engagement. Two-thirds of the infants were mildly anemic, no treatment effects on hemoglobin concentration were observed, and hemoglobin was not associated with measures of development or behavior. CONCLUSION: The beneficial effects of weekly iron and zinc supplementation on motor development and orientation-engagement suggest that infants benefit from these minerals when administered together. | en |
dc.format.extent | 137592 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | en |
dc.subject | Anemia iron-deficiency | en |
dc.subject | Child development | en |
dc.subject | Drug effects | en |
dc.subject | physiology | en |
dc.subject | Dietary supplements | en |
dc.subject | Double-blind method | en |
dc.subject | Drug combinations | en |
dc.subject | Drug synergism | en |
dc.subject | Exploratory behavior | en |
dc.subject | Female | en |
dc.subject | Growth | en |
dc.subject | Humans | en |
dc.subject | Infant behavior | en |
dc.subject | physiology | en |
dc.subject | Infant nutrition disorders | en |
dc.subject | Drug therapy | en |
dc.subject | Iron, dietary | en |
dc.subject | Micronutrients | en |
dc.subject | Bangladesh | en |
dc.subject | Zinc | en |
dc.title | Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants | en |
dc.type | Article | en |
Appears in Collections: | A. Original papers |
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2004-AmJClinNutr-903-BlackMM.pdf | 134.37 kB | Adobe PDF | View/Open Request a copy |
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