Selective destruction of skin permeability activity in cholera toxin: effect of acid on cholera enterotoxin
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bhattacharjee, Apurba K. | - |
| dc.contributor.author | Mosley, Wiley Henry | - |
| dc.date.accessioned | 2007-12-26T06:47:26Z | - |
| dc.date.available | 2007-12-26T06:47:26Z | - |
| dc.date.issued | 1973 | - |
| dc.identifier.citation | Infect Immun 1973 Aug;8(2):133-6 | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/498 | - |
| dc.description.abstract | The effect of treatment of purified cholera enterotoxin with acid at pH 2.0 for 1 h followed by neutralization of the acid on the biological activity of the toxin has been studied. It was found that the material loses 85 to 96% of its skin permeability activity and this loss is neither reversed nor increased after 28 days of storage at 5 to 10 C. Other biological properties such as diarrheagenic activity, lipolysis-stimulating activity, and the lethal dose for mice remain unaffected by acid treatment. These observations indicate that the skin permeability activity is more sensitive to relatively minor changes in molecular structure than are the diarrheal, lipolytic, and mouse lethality activities | en |
| dc.format.extent | 224899 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en | en |
| dc.subject | Cholera toxin | en |
| dc.subject | Permeability | en |
| dc.subject | Vibrio cholera | en |
| dc.subject | Enterotoxin | en |
| dc.title | Selective destruction of skin permeability activity in cholera toxin: effect of acid on cholera enterotoxin | en |
| dc.type | Article | en |
| Appears in Collections: | A. Original papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1973-InfectImmun-133-BhattacharjeeAK.pdf | 219.63 kB | Adobe PDF | View/Open Request a copy |
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