Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up

Full metadata record
DC FieldValueLanguage
dc.contributor.authorClemens, John D.-
dc.contributor.authorSack, David A.-
dc.contributor.authorHarris, Jeffrey R.-
dc.contributor.authorvan, Loon Frederik-
dc.contributor.authorChakraborty, J.-
dc.contributor.authorAhmed, Faruque-
dc.contributor.authorRao, M.R.-
dc.contributor.authorKhan, M.R.-
dc.contributor.authorYunus, Md-
dc.contributor.authorHuda, N.-
dc.contributor.authorStanton, Bonita F.-
dc.contributor.authorKay, Bradford A.-
dc.contributor.authorWalter, Stephen-
dc.contributor.authorEeckels, Roger-
dc.contributor.authorSvennerholm, Ann-Mari-
dc.contributor.authorHolmgren, Jan-
dc.identifier.citationLancet 1990 Feb 3;335(8684):270-3en
dc.description.abstractThe protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).en
dc.format.extent967864 bytes-
dc.subjectAdministration, Oralen
dc.subjectAge Factorsen
dc.subjectChi-Square Distributionen
dc.subjectChild, Preschoolen
dc.subjectCholera Vaccinesen
dc.subjectDouble-Blind Methoden
dc.subjectDrug Evaluationen
dc.subjectFollow-Up Studiesen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectTime Factorsen
dc.subjectVaccines, Inactivateden
dc.titleField trial of oral cholera vaccines in Bangladesh: results from three-year follow-upen
Appears in Collections:A. Original papers

Files in This Item:
File Description SizeFormat 
1990-Lancet-270-ClemensJD.pdf945.18 kBAdobe PDFView/Open    Request a copy

This item is protected by original copyright