Antimicrobial resistance and serotype distribution of Streptococcus pneumoniae strains causing childhood infections in Bangladesh, 1993 to 1997

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dc.contributor.authorSaha, Samir K.-
dc.contributor.authorRikitomi, N.-
dc.contributor.authorRuhulamin, M.-
dc.contributor.authorMasaki, H.-
dc.contributor.authorHanif, M.-
dc.contributor.authorIslam, Maksuda-
dc.contributor.authorWatanabe, K.-
dc.contributor.authorAhmed, K.-
dc.contributor.authorMatsumoto, K.-
dc.contributor.authorSack, R.B.-
dc.contributor.authorNagatake, T.-
dc.identifier.citationJ Clin Microbiol 1999 Mar;37(3):798-800en
dc.description.abstractThree hundred sixty-two Streptococcus pneumoniae strains were isolated from children under 5 years of age at Dhaka Shishu (Children) Hospital from 1993 to 1997. The strains were isolated from blood (n = 105), CSF (n = 164), ear swab (n = 61), eye swab (n = 20), and pus (n = 12). Of the 362 isolates, 42 (11.6%) showed intermediate resistance (MIC, <0.1 microgram/ml) and only 4 (1.1%) showed complete resistance (MIC, >2.0 microgram/ml) to penicillin. Penicillin resistance exhibited a strong relationship with serotype 14; 47.8% of the penicillin-resistant strains belonged to this type. A remarkably high (64.1%) resistance to co-trimoxazole was observed, along with a significant increase during the time period studied; there was no relationship to capsular type. By way of contrast, penicillin resistance did not show any significant change during the study period. Resistance to chloramphenicol (2.2%) and erythromycin (1.1%) was rare. The high resistance to co-trimoxazole and its increasing trend demand elucidation of the clinical impact of pneumonia treatment by this antimicrobial and reconsideration of the World Health Organization recommendation for co-trimoxazole administration to children with community-acquired pneumonia at the health care worker level in Bangladeshen
dc.format.extent193689 bytes-
dc.subjectStreptococcus pneumoniaeen
dc.subjectDrug resistance, Microbialen
dc.subjectPneumococcal infectionsen
dc.subjectisolation & purificationen
dc.titleAntimicrobial resistance and serotype distribution of Streptococcus pneumoniae strains causing childhood infections in Bangladesh, 1993 to 1997en
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