Glutamine is superior to glucose in stimulating water and electrolyte absorption across rabbit ileum

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dc.contributor.authorIslam, S.-
dc.contributor.authorMahalanabis, Dilip-
dc.contributor.authorChowdhury, A.K.A.-
dc.contributor.authorWahed, M.A.-
dc.contributor.authorRahman, A.S.M.H.-
dc.identifier.citationDig Dis Sci 1997 Feb;42(2):420-3en
dc.description.abstractL-Glutamine is the primary metabolic fuel of the intestinal mucosa. This in vivo study compares the effect of L-glutamine 50 mM with that of D-glucose 50 mM on water and electrolyte absorption in jejunal and ileal loops of healthy rabbits. Using polyethylene glycol (PEG) as a nonabsorbable marker and an incubation at 37 degrees C, we found that absorption of water (P = 0.000), sodium (P = 0.002), potassium (P = 0.001), and chloride (P = 0.003) from the glutamine electrolyte solution was greater than from the glucose electrolyte solution in the ileum. A similar trend was shown in the jejunum. We conclude that L-glutamine may be a useful component to be tested in oral rehydration solutions for treating diarrheal dehydrationen
dc.format.extent165263 bytes-
dc.subjectIon transporten
dc.subjectDisease models, Animalen
dc.subjectIntestinal mucosaen
dc.subjectIntestinal absorptionen
dc.subjectDiarrheal diseasesen
dc.subjectOral rehydration solutionen
dc.subjectOral therapyen
dc.titleGlutamine is superior to glucose in stimulating water and electrolyte absorption across rabbit ileumen
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