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Monoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic application

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dc.contributor.authorQadri, Firdausi-
dc.contributor.authorMohi, M. Golam-
dc.contributor.authorChowdhury, Ashrafuzzamn-
dc.contributor.authorAlam, Khorshid-
dc.contributor.authorAzim, Tasnim-
dc.contributor.authorSears, Cynthia-
dc.contributor.authorSack, R. Bradley-
dc.contributor.authorAlbert, M. John-
dc.date.accessioned2008-11-11T02:03:46Z-
dc.date.available2008-11-11T02:03:46Z-
dc.date.issued1996-09-
dc.identifier.citationClin Diagn Lab Immunol 1996 Sep;3(5):608-10en
dc.identifier.urihttp://hdl.handle.net/123456789/2028-
dc.description.abstractA monoclonal antibody, ICT11, specific for the toxin of enterotoxigenic Bacteroides fragilis (ETBF) neutralized the cytotoxic effect of the toxin on human colonic cell line HT-29/C1. In an evaluation using 115 diarrheal stool specimens and culture as the "gold standard," the assay showed a sensitivity of 85% and a specificity of 100%. An ICT11-based sandwich enzyme-linked immunosorbent assay showed a sensitivity of 100% and a specificity of 98% for direct detection of toxin from stool samples compared with those of culture. Thus, ICT11-based assays will be useful for screening for ETBFen
dc.format.extent142309 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.subjectAntibodies, Monoclonalen
dc.subjectBacteriodes fragilisen
dc.subjectEnterotoxinsen
dc.subjectDiagnosis, Laboratoryen
dc.subjectBangladeshen
dc.titleMonoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic applicationen
dc.typeArticleen
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