Trimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial

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dc.contributor.authorAlam, N.H.-
dc.contributor.authorBardhan, P.K.-
dc.contributor.authorHaider, R.-
dc.contributor.authorMahalanabis, Dilip-
dc.date.accessioned2008-11-04-
dc.date.available2008-11-04-
dc.date.issued1995-06-
dc.identifier.citationArch Dis Child 1995 Jun;72(6):483-6en
dc.identifier.urihttp://hdl.handle.net/123456789/1973-
dc.description.abstractThe efficacy of an absorbable antimicrobial agent trimethoprim-sulphamethoxazole (TMP-SMX) in the management of children with persistent diarrhoea was evaluated in a double blind, randomised, and placebo controlled trial. Of the 55 patients studied, 28 received TMP-SMX, and 27 received placebo. A trend in stool weight reduction was observed from the third day after the drug was started, and the reduction was statistically significant on day 6 and day 7. However, the difference in total stool output (g/kg) up to day 7 was not significantly different between the two groups. The proportion of children whose diarrhoea resolved by day 7 (therapeutic success) was significantly more in the treatment group compared with the placebo group (23 v 15). Additionally, mean duration of diarrhoea in the group that received TMP-SMX was less compared with the placebo group (6.0 v 8.3 days); this difference, however, was not significant. Hospital infection (probably nosocomial infection) was significantly less in the TMP-SMX treated group (1 v 10). The results of our study indicate that TMP-SMX has a clinical benefit in respect of reducing the stool output, and higher recovery rate within seven days of treatment. In addition, it prevented possible hospital acquired infectionen
dc.format.extent202279 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.subjectTrimeethoprim-sulphamethoxazole combinationen
dc.subjectDiarrhea, Persistanten
dc.subjectRandomized controlled trialen
dc.subjectDiarrhea, Infantileen
dc.subjectDouble- blind methoden
dc.subjectBangladeshen
dc.titleTrimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trialen
dc.typeArticleen
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