Trimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Alam, N.H. | - |
dc.contributor.author | Bardhan, P.K. | - |
dc.contributor.author | Haider, R. | - |
dc.contributor.author | Mahalanabis, Dilip | - |
dc.date.accessioned | 2008-11-04 | - |
dc.date.available | 2008-11-04 | - |
dc.date.issued | 1995-06 | - |
dc.identifier.citation | Arch Dis Child 1995 Jun;72(6):483-6 | en |
dc.identifier.uri | http://hdl.handle.net/123456789/1973 | - |
dc.description.abstract | The efficacy of an absorbable antimicrobial agent trimethoprim-sulphamethoxazole (TMP-SMX) in the management of children with persistent diarrhoea was evaluated in a double blind, randomised, and placebo controlled trial. Of the 55 patients studied, 28 received TMP-SMX, and 27 received placebo. A trend in stool weight reduction was observed from the third day after the drug was started, and the reduction was statistically significant on day 6 and day 7. However, the difference in total stool output (g/kg) up to day 7 was not significantly different between the two groups. The proportion of children whose diarrhoea resolved by day 7 (therapeutic success) was significantly more in the treatment group compared with the placebo group (23 v 15). Additionally, mean duration of diarrhoea in the group that received TMP-SMX was less compared with the placebo group (6.0 v 8.3 days); this difference, however, was not significant. Hospital infection (probably nosocomial infection) was significantly less in the TMP-SMX treated group (1 v 10). The results of our study indicate that TMP-SMX has a clinical benefit in respect of reducing the stool output, and higher recovery rate within seven days of treatment. In addition, it prevented possible hospital acquired infection | en |
dc.format.extent | 202279 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | en |
dc.subject | Trimeethoprim-sulphamethoxazole combination | en |
dc.subject | Diarrhea, Persistant | en |
dc.subject | Randomized controlled trial | en |
dc.subject | Diarrhea, Infantile | en |
dc.subject | Double- blind method | en |
dc.subject | Bangladesh | en |
dc.title | Trimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial | en |
dc.type | Article | en |
Appears in Collections: | A. Original papers |
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1995-ArchDisChild-483-AlamNH.pdf | 197.54 kB | Adobe PDF | View/Open Request a copy |
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