Cytokines in the stools of children with complicated shigellosis

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dc.contributor.authorAzim, Tasnim-
dc.contributor.authorHalder, R. Chandra-
dc.contributor.authorSarker, M. Safiullah-
dc.contributor.authorAhmed, Sharmeen-
dc.contributor.authorHamadani, Jena-
dc.contributor.authorChowdhury, Akhtaruzzaman-
dc.contributor.authorQadri, Firdausi-
dc.contributor.authorSalam, M. Abdus-
dc.contributor.authorSack, R. Bradley-
dc.contributor.authorAlbert, M. John-
dc.identifier.citationClin Diagn Lab Immunol 1995 Jul;2(4):492-5en
dc.description.abstractThe pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-alpha in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool IL-6 and TNF-alpha concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and < 0.001, respectively) or in uninfected children (P < 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-alpha in stoolen
dc.format.extent176005 bytes-
dc.subjectShigella dysenteriaeen
dc.subjectDysentery, Bacillaryen
dc.titleCytokines in the stools of children with complicated shigellosisen
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