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|Title: ||Zinc supplementation in children with cholera in Bangladesh : randomised controlled trial|
|Authors: ||Roy, S. K.|
Hossain, M. Jahangir
Diarrhea, Infantile-prevention & control
|Issue Date: ||2008 |
|Citation: ||British Medical Journal Online|
|Abstract: ||Objective To investigate the impact of zinc
supplementation in children with cholera.
Design Double blind, randomised, placebo controlled
Setting Dhaka Hospital, Bangladesh.
Participants 179 children aged 3-14 years with watery
diarrhoea and stool dark field examination positive for
Vibrio cholerae and confirmed by stool culture.
Intervention Children were randomised to receive 30 mg
elemental zinc per day (n=90) or placebo (n=89) until
recovery. All children received erythromycin suspension
orally in a dose of 12.5mg/kg every six hours for three days.
Main outcome measures Duration of diarrhoea and stool
Results 82 children in each group completed the study.
More patients in the zinc group than in the control group
recovered by two days (49% v 32%, P=0.032) and by three
days (81% v 68%, P=0.03). Zinc supplemented patients
had 12% shorter duration of diarrhoea than control
patients (64.1 v 72.8 h, P=0.028) and 11% less stool
output (1.6 v 1.8 kg/day, P=0.039).Conclusion Zinc supplementation significantly reduced the duration of diarrhoea and stool output in children with cholera. Children with cholera should be supplemented with zinc to reduce its duration and severity. Trial registration Clinical trials NCT00226616|
|Appears in Collections:||Child health research papers|
Nutrition research papers
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