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Title: Evaluation of the plant extract (Hirtacin) in a rabbit model of shigellosis
Authors: Rahman, Qazi Khaleda
Ahsan, Chowdhury Rafiqul
Ahmed, Kamaluddin
Rabbani, G.H.
Keywords: shigella
Cholera
Issue Date: 
Citation: J Diarrhoeal Dis Res 1998 Jun;16(2):145
Abstract: Objective: Evaluate the efficacy of the plant extract hirtacin in a rabbit model of shigellosis. Methodology: Cecal-ligated rabbits were inoculated with Shigellaflexneri 2a, and after 24 hours, three groups of rabbits were treated with hirtacin, ciprofloxacin, and placebo respectively for five days. Results: The plant extract hirtacin and ciprofloxacin significantly reduced myeloperoxidase (MPO) level in plasma which serves as a marker of inflammation, while the MPO level was still high in the placebo group after five days of treatment. Also the clinical features of both the drug-treated groups showed complete remission from dysentery, while dysenteric symptoms still persisted in the placebo group after five days. Conclusion: It is concluded that the plant extract hirtacin has a potent therapeutic activity in shigellosis.
URI: http://hdl.handle.net/123456789/392
ISSN: 0253-8768
Appears in Collections:Public health sciences conference papers

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