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| Title: | Evaluation of the plant extract (Hirtacin) in a rabbit model of shigellosis |
| Authors: | Rahman, Qazi Khaleda
Ahsan, Chowdhury Rafiqul
Ahmed, Kamaluddin
Rabbani, G.H. |
| Keywords: | shigella
Cholera |
| Issue Date: | |
| Citation: | J Diarrhoeal Dis Res 1998 Jun;16(2):145 |
| Abstract: | Objective: Evaluate the efficacy of the plant extract hirtacin in a rabbit model of shigellosis.
Methodology: Cecal-ligated rabbits were inoculated with Shigellaflexneri 2a, and after 24 hours, three groups of rabbits were treated with hirtacin, ciprofloxacin, and placebo respectively for five days.
Results: The plant extract hirtacin and ciprofloxacin significantly reduced myeloperoxidase (MPO) level in plasma which serves as a marker of inflammation, while the MPO level was still high in the placebo group after five days of treatment. Also the clinical features of both the drug-treated groups showed complete remission from dysentery, while dysenteric symptoms still persisted in the placebo group after five days.
Conclusion: It is concluded that the plant extract hirtacin has a potent therapeutic activity in shigellosis. |
| URI: | http://hdl.handle.net/123456789/392 |
| ISSN: | 0253-8768 |
| Appears in Collections: | Public health sciences conference papers
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| 1998-JDiarDisRes-145-RahmanQK.pdf | | 19Kb | Adobe PDF | View/Open |
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