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Title: Role of nitric oxide in the pathogenesis of shigellosis and cholera in children
Authors: Islam, Sufia
Fuchs, G.J.
Chowdhury, A.K.
Rahman, A.
Miller, M.
Rabbani, G.H.
Keywords: Shigella
Shigella dysenteriae
Infantile, Diarrhea
Issue Date: 1998
Citation: J Diarrhoeal Dis Res 1998 Jun;16(2):109
Abstract: Objective: Evaluate the role of nitric oxide in the pathogenesis of shigeltosis and cholera in children. Methodology: Concentrations of nitrite, a stable metabolite of nitric oxide (by Griess reaction) in urine and serum samples of 24 patients aged 1-5 years (10 shigellosis, 14 cholera) were determined. Tests were done on admission to hospital with acute diarrhoea and repeated at early convalescence after 3-7 days of specific antimicrobial therapy. Results: In children with shigellosis, urinary nitrite excretion (nM/mg creatinine) was significantly increased during acute illness compared to early convalescence, median (range): 7061 (1046-18264) vs. 4316 (2369-12428. p<0.05). Concentration of nitric oxide in serum (mmol/L) also significantly (p<0.05) increased during acute illness compared to convalescence values: 206 (159-214) vs. 104 (102-273). Similarly, in children with cholera, both urinary and serum nitrite excretions were significantly (p<0.05) elevated during acute illness compared to convalescence: 5034±1345 vs. 2178±404 (urine); 450±89 vs. 201±56 (serum). Conclusion: These results indicate that production of nitric oxide is increased both in acute shigellosis and cholera, more markedly in the former infection because of colonic inflammation. Urinary nitrite excretion can be a useful marker of severity of these infections.
URI: http://hdl.handle.net/123456789/366
ISSN: 0253-8768
Appears in Collections:Public health sciences conference papers

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