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Title: Familial aggregation of Vibrio cholerae-associated infection in Matlab, Bangladesh
Authors: Rahman, Kazi Mizanur
Duggal, Priya
Harris, Jason B.
Streatfield, Peter Kim
Ryan, Edward T.
Calderwood, Stephen B.
Qadri, Firdausi
Yunus, Mohammad
LaRocque, Regina C.
Keywords: Cholera-epidemiology
Case-Control Studies
Diarrhea-epidemiology
Environmental Exposure Family
Genetic Predisposition to Disease
Multivariate Analysis
Odds Ratio
Risk Factors
Vibrio cholerae
Bangladesh
Issue Date: Dec-2009
Citation: J Health Popul Nutr 2009 Dec;27(6):733-8
Abstract: Vibrio cholerae is a major cause of diarrhoeal illness in endemic regions, such as Bangladesh. Understanding the factors that determine an individual's susceptibility to infection due to V. cholerae may lead to improved prevention and control strategies. Increasing evidence suggests that human genetic factors affect the severity of V. cholerae-associated infection. This study, therefore, sought to characterize the heritable component of susceptibility to infection due to V. cholerae using the Matlab Health and Demographic Surveillance System database of the International Centre for Diarrhoeal Disease Research, Bangladesh. In total, 144 pedigrees that included a cholera patient and 341 pedigrees without a cholera patient were evaluated during 1 January-31 December 1992. The odds of the sibling of a patient being admitted with cholera were 7.67 times the odds of the sibling of an unaffected individual being admitted with cholera [95% confidence interval (CI) 2.40-24.5, p < 0.001], after adjustment for gender, age, socioeconomic status, and hygiene practices. Although exposure to environmental reservoirs is essential in the epidemiology of cholera, household-specific factors, such as familial relatedness to an index case, may also be important determinants of risk of cholera. Further analysis of human genetic factors that contribute to susceptibility to cholera may be productive
URI: http://hdl.handle.net/123456789/3020
Appears in Collections:Child health research papers

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