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Title: Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin
Authors: Sarker, Shafiqul A.
Pant, Neha
Juneja, Lekh R.
Hammarström, Lennart
Keywords: Animals, Suckling
Antibodies, Viral-biosynthesis
Antigens, Viral-immunology
Diarrhea-immunology
Diarrhea-prevention & control
Diarrhea-virology
Disease Models, Animal
Egg Yolk
Immunization, Passive
Humans
Mice
Random Allocation
Rotavirus Infections-immunology
Issue Date: Dec-2007
Citation: J Health Popul Nutr 2007 Dec;25(4):465-8
Abstract: The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting
URI: http://hdl.handle.net/123456789/2991
Appears in Collections:Laboratory sciences research papers

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