DSpace About icddr,b  
 

DSpace at icddr,b >
Cholera Research Laboratory(1962-1978) >
Cholera research laboratory research papers >

 

Title: Single-dose doxycycline for cholera
Authors: Sack, David A.
Islam, Sirajul
Rabbani, Hassan
Islam, Asma
Keywords: Cholera
Doxycycline
Drug therapy
Humans
Male
Issue Date: Sep-1978
Citation: Antimicrob Agents Chemother 1978 Sep;14(3):462-4
Abstract: To determine the efficacy of single-dose doxycycline in the treatment of cholera, we carried out a randomized prospective trial in 65 patients. Treatment consisted of either a single dose of 200 mg of doxycycline (or 4 mg/kg in patients less than 15 years old) or multiple doses of doxycycline, 500 mg over 4 days (or 10 mg/kg in patients less than 15 years old). There were no differences between the groups in the volumes of intravenous fluid required, volumes of diarrheal stool, or durations of diarrhea. The mean duration of positive stool cultures for Vibrio cholerae was similar for the two groups, although in both groups several patients continued to excrete Vibrios in the stool for more than 3 days. Blood levels of antibiotic demonstrated that the doxycycline was absorbed in spite of the rapid transit time associated with severe diarrhea. These results suggest that although tetracycline remains the drug of choice for cholera, doxycycline is a reasonable alternative, and that a single dose of 200 mg (4 mg/kg in children) is effective clinically.
URI: http://hdl.handle.net/123456789/2730
Appears in Collections:Cholera research laboratory research papers

Files in This Item:

File Description SizeFormat
1978-AntimicrobAgentsChemo-462-SackDA .pdf483KbAdobe PDFView/Open


This item is protected by original copyright

All items in DSpace are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2006 MIT and Hewlett-Packard - Feedback