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Title: Arsenic exposure in pregnancy: a population-based study in Matlab, Bangladesh
Authors: Vahter, Marie E.
Li, Li
Nermell, Barbro
Rahman, Anisur
Arifeen, Shams El
Rahman, Mahfuzar
Persson, Lars Ake
Ekstrom, Eva-Charlotte
Keywords: Arsenic
Arsenic exposure
Spatial variation
Pregnancy
Bangladesh
Issue Date: 5-Sep-2007
Series/Report no.: J Health Popul Nutr
2006 Jun;24(2):236-245
Abstract: This study assessed the exposure of pregnant women to arsenic in Matlab, Bangladesh, an area with highly-elevated concentrations of arsenic in tubewells, by measuring concentrations of arsenic in urine. In a defined administrative area, all new pregnancies were identified by urine test in gestational week 6-8, and women were asked to participate in the assessment of arsenic exposure. Urine for analysis of arsenic was collected immediately and in gestational week 30. In total, 3,426 pregnant women provided urine samples during January 2002–March 2003. There was a considerable variation in urinary concentrations of arsenic (total range 1-1,470 µg/L, adjusted to specific gravity 1.012 g/mL), with an overall median concentration of 80 µg/L (25th and 75th percentiles were 37 and 208 µg/L respectively). Similar concentrations were found in gestational week 30, indicating no trend of decreasing exposure, despite the initiation of mitigation activities in the area. Arsenic exposure was negatively associated with socioeconomic classes and achieved educational level. There were marked geographical variations in exposure. The results emphasize the urgent need for efficient mitigation activities and investigations of arsenic-related reproductive effects
URI: http://hdl.handle.net/123456789/158
Appears in Collections:Public health sciences research papers

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