DSpace About icddr,b  
 

DSpace at icddr,b >
Public Health Sciences >
Public health sciences research papers >

 

Title: Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh
Authors: Broek, J.M. van den
Roy, S.K.
Khan, W.A.
Ara, G
Chakraborty, B.
Islam, S.
Banu, B.
Keywords: Shigella
Dysentery
Bacillary
Infant nutrition disorders
Child nutrition disorders
Infant mortality
Child mortality
Risk factors
Case-control studies
Bangladesh
Issue Date: 5-Sep-2007
Series/Report no.: J Health Popul Nutr
2005 Sep;23(3):259-265
Abstract: To determine the risk factors for death of severely-malnourished Bangladeshi children with shigellosis, a case-control study was conducted at the Clinical Research and Service Centre of ICDDR,B: Centre for Health and Population Research in Dhaka, Bangladesh. One hundred severely-malnourished children (weight-for-age <60% of median of the National Center for Health Statistics), with a positive stool culture for Shigella dysenteriae type 1 or S. flexneri, who died during hospitalization, were compared with another 100 similar children (weight-for-age <60% and with S. dysenteriae type 1 or S. flexneri-associated infection) discharged alive. Children aged less than four years were admitted during December 1993_January 1999. The median age of the cases who died or recovered was 9 months and 12 months respectively. Bronchopneumonia, abdominal distension, absent or sluggish bowel sound, clinical anaemia, altered consciousness, hypothermia, clinical sepsis, low or imperceptible pulse, dehydration, hypoglycaemia, high creatinine, and hyperkalaemia were all significantly more frequent in cases than in controls. In multivariate regression analysis, altered consciousness (odds ratio [OR]=2.6, 95% confidence interval [CI] 1.0-6.8), hypoglycaemia (blood glucose <3 mmol/L (OR= 7.8, 95% CI 2.9-19.6), hypothermia (temperature <36 °C) (OR = 5.7, 95% CI 1.5-22.1), and bronchopneumonia (OR = 2.5, 95% CI 1.1-5.5) were identified as significant risk factors for mortality. Severely-malnourished children with shigellosis having hypoglycaemia, hypothermia, altered consciousness and/or bronchopneumonia were at high risk of death. Based on the findings, the study recommends that early diagnosis of shigellosis in severely-malnourished children and assertive therapy for proper management to prevent development of hypothermia, hypoglycaemia,bronchopneumonia, or altered consciousness and its immediate treatment are likely to reduce Shigella-related mortality in severely-malnourished children.
URI: http://hdl.handle.net/123456789/147
Appears in Collections:Public health sciences research papers

Files in This Item:

File Description SizeFormat
2005-JHealthPoulNutr-259-Broek.pdf133KbAdobe PDFView/Open


This item is protected by original copyright

All items in DSpace are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2006 MIT and Hewlett-Packard - Feedback